The study investigates the binding interactions of saroglitazar and ferulic acid with human ketohexokinase (KHK), an enzyme implicated in MASLD pathogenesis, aiming to propose potential therapeutic interventions for this debilitating condition. We collected information about compounds, compound-related targets, and MASLD-related genes from extensive databases and identified important targets and pathways using a protein-protein interaction network-based method. This evidence concerns the gene KHK and metabolic dysfunction-associated steatotic liver disease.