Although recent studies have shown that elevated HIF-1α can delay IVD degeneration and has a protective effect on neurons in in vitro ischemia models [30–32], previous studies have shown that HIF-1α and its mediated metabolic reprogramming can regulate various inflammatory cell phenotypes, including those of macrophages and T cells, and promote the expression of inflammatory genes [33, 34]. This evidence concerns the gene HIF1A and ischemia.