Many pathways, such as MAPK (Moon and Ro 2021), PI3K‐Akt–mTOR (Sun et al. 2021), Wnt‐β‐catenin (Vilchez et al. 2016), proangiogenic, and epidermal growth factor receptor pathway (Prenner and Kulik 2016) are involved in the pathogenesis of HCC. Here, AKT1 is linked to hepatocellular carcinoma.