Increasing evidence has shown that the NF-κB canonical pathway is involved in the pathogenesis of liver disease via transcriptional regulation of a variety of target genes, such as interleukin 6 (IL-6), or by activating additional cell signaling pathways, such as signal transducer and activator of transcription 3 (STAT3) (54, 55). Here, NFKB1 is linked to liver disorder.