CD33 and acute myeloid leukemia: Both double-targeted single-chain Fv trisomy (sctb) and single-targeted sctb use isolated monocytes (MNC) as effector cells, which can effectively induce antibody-dependent cytotoxicity (ADCC) of two different acute myeloid leukemia (AML) -derived CD33 and CD123 double-positive cell lines at low concentrations (80).