NFKB1 and acute myeloid leukemia: In addition, studies have pointed out that by combining PLGA nanoparticles with anti-d44 antibody to form PLGA-antid44-PTL complexes and encapsulating parthenolide, an effective nuclear factor kappa B (NF-κB) inhibitor, the cellular uptake efficiency of drugs on acute myeloid leukemia cells can be significantly improved, thereby more effectively inhibiting the proliferation of these cells (185).