NFKB1 and acute myeloid leukemia: It has been reported that a NLS peptide-functionalized gold nanoparticle loaded with AS1411 and anti-221 can accurately bind AS1411 and anti-221 in vitro and in vivo, and target the key molecules in the NCL/miR-221/NFκB/DNMT1 signaling pathway, thereby effectively inhibiting the growth of AML cells (180).