Research by Povero et al., identified Solute Carrier family 27, member 5 (SLC27A5) as a distinct indicator for circulating lipotoxic hepatocyte-originating EVs in MAFLD and MASH, whereas Asialoglycoprotein Receptor 1 (ASGR1) is a specific marker for hepatocyte-derived EVs in cirrhosis, and increased with disease progression (57). Here, SLC27A5 is linked to Cirrhosis.