Proteomics analysis of lipotoxic EVs derived from serum samples and hepatocytes of MASH patients revealed that haptoglobin, Vascular Non-Inflammatory Molecule-1 (Vanin 1), and the Insulin-Like Growth Factor-Binding Protein Complex Acid Labile Subunit (IGF-BP ALS) could serve as biomarkers for detecting EVs originating from hepatocytes in MASH patients (54). This evidence concerns the gene VNN1 and metabolic dysfunction-associated steatohepatitis.