PFKFB3 and Decreased liver function: Studies have demonstrated that Garlic-Derived Exosomes (GDE) effectively suppress inflammation in macrophages and improve liver dysfunction in HFD-fed mice, with miR-396e in GDE playing a crucial role in mediating interactions between macrophages and hepatocytes by targeting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) (140).