GLP1R and obesity due to melanocortin 4 receptor deficiency: Additionally, a potent GLP-1 RA, namely, semaglutide was reassessed for a link to suicidal ideation, however a large TriNetX Network analysis (240,618 patients) did not demonstrate higher risks of suicidal ideation with semaglutide compared with non-GLP1R agonist anti-obesity or anti-diabetes medications (Wang et al., 2024a).