IL7 and osteosarcoma: In one study, a CAR T cell co-expressing CXCR5 and IL-7 (C5/IL7-CAR-T) was designed to enhance the survival of CAR T cells and reduce cell depletion and apoptosis through the pSTAT5 signaling pathway, showing significant efficacy in the treatment of osteosarcoma (Hui et al., 2024).