Uncoupling protein-1 (UCP1) IHC staining analysis of gonadal WAT showed an obvious phenotypic switch from white to brown adipose, and the percentage of the brown area increased from 0.11 to 0.29 in cachectic mice (P < 0.01, Figure 3B), which is consistent with the previous finding of cancer cachexia in mice (Petruzzelli et al., 2014). Here, UCP1 is linked to cancer.