The reference agent FFAR2 exerted protective effects on tumor-free body weight (P < 0.05), gastrocnemius muscle (P < 0.05), soleus muscle (P < 0.01), epididymal fat (P < 0.05), the relative ratio of gastrocnemius muscle weight to body weight (P < 0.05), the relative ratio of epididymal fat weight to body weight (P < 0.05), spleen index (P < 0.05), and thymus index (P < 0.01) in cancer cachectic mice. This evidence concerns the gene FFAR2 and cancer.