A study exploring the neuroendocrine characteristics of NB targeted the delta-like ligand 3 (DLL3), an inhibitory Notch ligand selectively upregulated in neuroendocrine tumors where it potentiates tumor proliferation and invasion by activating the Notch and the SNAI1/Snail signaling pathways (51–53). The gene discussed is DLL3; the disease is neuroblastoma.