Several NB cell lines, NB-PDXs, and xenografts1)GPC2Mod, MYCN non-amplified, ALK wild type, TP53 wild type;2)Engineered mouse NB 9464D-GPC2 isogenic cell line in the immunocompetent C57BL/6J mouse strain;3)NB-PDX model COG-N-421x (GPC2Hi, MYCN amplified, ALK wild type, TP53 wild type;Significantly locally advanced COG-N-421x PDXs;High-GPC2-expressing NB cell-line-derived xenograft SK-N-AS (GPC2Hi, MYCN non-amplified, ALK wild type, TP53 mutated. The gene discussed is TP53; the disease is neuroblastoma.