PTEN and cancer: Furthermore, miRNAs such as miR-301a [44], [45], miR-214 [46], [47], miR-494 [48], [49], and a cluster including miR-155–5p, miR-130b, miR-616, miR-19, miR-92a, miR-10a, miR-106a, miR-429, miR-26a, and miR-486–5p [50], [51] downregulate PTEN expression by directly targeting its mRNA in various cancers and other diseases.