OPRK1 and obesity due to melanocortin 4 receptor deficiency: Collectively, these lines of investigation underscore that anhedonia can be modulated by multiple therapeutic strategies: pharmacological agents (dopamine agonists, KOR antagonists, lumateperone, trazodone), hormonal interventions (TE2 in perimenopausal women), and lifestyle/dietary adjustments (food restriction in obesity, acute blueberry supplementation).