Additionally, a Mendelian randomization (MR) study utilizing summary data from a genome-wide association study (GWAS) of the ApoB/ApoA1 ratio (BAR), Lp(a), and TG in a European population confirmed a causal relationship between BAR and CHD, emphasizing that BAR was an independent risk factor for CHD (34). This evidence concerns the gene APOA1 and coronary artery disorder.