After adjusting for confounding factors, including age, sex, BMI, smoking, alcohol intake, medical history (such as hypertension, diabetes, and hyperlipidemia), and multivessel lesions, the results showed that RC and lipid ratios (TG/HDL-C, TC/HDL-C, LDL-C/HDL-C, and ApoB/ApoA) were independent risk factors for moderate-to-severe coronary artery stenosis. The gene discussed is APOA1; the disease is hyperlipidemia.