Interferon-γ (IFNγ) is the key cytokine in antitumor immunity and can affect a variety of cells in the TME of pancreatic cancer (Delitto et al., 2015), Although the study of Huimin Huang demonstrated the role of CXCL10 in the immune infiltration of PAAD (Huang et al., 2021), it was not comprehensive enough in the prognostic biomarkers and immune infiltration mechanism, and the research content was relatively limited. This evidence concerns the gene IFNG and familial pancreatic carcinoma.