The authors also identified a CA/IDC-P immunosuppressive cancer-associated fibroblast (CAF) gene signature based on four upregulated genes (CTHRC1, ASPN, FAP, and ENG), which they termed “CAFÉ CAF,” and which is associated with adverse outcomes (42)— worse PCa progression-free survival in The Cancer Genome Atlas (TCGA) PanCancer Atlas prostate adenocarcinoma cohort (77) and worse disease-free survival in the Memorial Sloan Kettering Cancer Center (MSKCC) prostate adenocarcinoma cohort (42, 78). The gene discussed is ASPN; the disease is prostate adenocarcinoma.