KLK3 and posterior cortical atrophy: Fiñones et al, isolated and propagated androgen-independent cells from prostatectomy samples of early, localized (Stage-I) cases, grew them as spheroids, and then xenografted 22 of these as PDXs in intact and castrated SCID mice, generating histologically typical locally-invasive human PCa or undifferentiated cancers that lacked PSA expression (98).