Chen et al, identified a specific expression pattern with high levels of nuclear receptor interaction protein (NRIP) and AR, together with a low level of DNA damage binding protein 2 (DDB2) that was found more frequently in PCa with a cribriform pattern than in non-cribriform tumors, suggesting that disturbance of the balance between NRIP and DDB2 may change AR homeostasis and contribute to tumor aggressiveness in certain subtypes of prostate cancer (102). This evidence concerns the gene AR and prostate cancer.