DCAF6 and Familial prostate cancer: Chen et al, identified a specific expression pattern with high levels of nuclear receptor interaction protein (NRIP) and AR, together with a low level of DNA damage binding protein 2 (DDB2) that was found more frequently in PCa with a cribriform pattern than in non-cribriform tumors, suggesting that disturbance of the balance between NRIP and DDB2 may change AR homeostasis and contribute to tumor aggressiveness in certain subtypes of prostate cancer (102).