BCR and cancer: In a meta-analysis of studies evaluating clinical outcomes in PCa with cribriform architecture, Russo et al, found that CA was associated with higher risk of ECE (odds ratio [OR] 1.96), seminal vesicle invasion (SVI) (OR: 2.89), and positive surgical margins (PSM) (OR: 1.88); they additionally showed that CA was associated with greater risk of BCR (hazard ratio [HR]: 2.14) and of cancer-specific mortality (CSM) (HR: 3.30) (119).