Contrarily, only 6/63 (9.5%) coinheritance of α-thalassemia had been observed among those within the transfusion-dependent β-thalassemia group, including homozygous β-thalassemia and β-thalassemia/Hb E. Coinheritance of α-thalassemia has been identified as a significant genetic factor contributing to ameliorating TM to TI in Sri Lanka, India, Italy, and Pakistan, with reported occurrences in 9/50 (18.0%), 16/73 (21.9%), 10/74 (19.5%), and 13/63 (20.6%) of TI patients, respectively [5, 17–19]. Here, GSTM1 is linked to thalassemia.