PRMT1 (protein arginine methyltransferase 1) is overexpressed in breast cancer, and PRMT1-mediated SRSF1 methylation and SRPK1-mediated SRSF1 phosphorylation are interdependent; PRMT1 enhances the phosphorylation, RNA-binding capacity, and exon splicing activity of SRSF1 through methylation of SRSF1, and this interaction enhances the oncogenic potential of SRSF1. The gene discussed is PRMT1; the disease is breast cancer.