VEGFA and neoplasm: For example, SRSF3 affects SRF mRNA splicing by directly binding to a specific motif (“CAUC”) in exon 6 of SRF (serum response factor), which then regulates the expression of downstream genes, such as VEGF (vascular endothelial growth factor), thereby enhancing the proliferation and migration of tumor cells and angiogenesis (Chen et al., 2022).