SRSF1 regulates PTPMT1 alternative splicing to promote breast cancer progression; SRSF2 regulates PLOD2 alternative splicing to promote breast cancer progression; SRSF3 promotes the expression of GRa and RACK1 to promote breast cancer progression; Loss of TDP43 inhibits breast cancer progression in coordination with SRSF3; Targeting PRMT1-mediated SRSF1 methylation inhibits breast cancer progression. Here, PTPMT1 is linked to breast cancer.