LINC01446 binds serine/arginine protein kinase 2 (SRPK2) to activate its downstream target serine/arginine splice factor 1 (SRSF1), and activation of the SRPK2-SRSF1 axis increases the splicing and expression of the VEGF isoform A165 (VEGFA165) and thus contributes to the HCC progression (Wu et al., 2024). Here, SRSF1 is linked to hepatocellular carcinoma.