LINC01446 binds serine/arginine protein kinase 2 (SRPK2) to activate its downstream target serine/arginine splice factor 1 (SRSF1), and activation of the SRPK2-SRSF1 axis increases the splicing and expression of the VEGF isoform A165 (VEGFA165) and thus contributes to the HCC progression (Wu et al., 2024). The gene discussed is SRPK2; the disease is hepatocellular carcinoma.