TULP3 and Leber congenital amaurosis: The authors showed that the anti-ageing effects of LCA are mediated through a conserved mechanism resulting in the activation of the lysosomal adenosine-monophosphate (AMP)-activated protein kinase (AMPK) pathway through the TUB-like protein 3 (TULP3)-sirtuin (SIRT)-vacuolar H+-ATPase (v-ATPase) axis to mediate the benefits of CR.