Yejun et al. (2023) found that miR-299-5p targeted SP3 to inhibit apoptosis in a PD cell model via the PTEN/AKT/mTOR pathway. Ge et al. (2019) found that miR-410 exerted neuroprotective effects on 6-OHDA-induced PD cell models by regulating the PTEN/AKT/mTOR signaling axis. Guo et al. (2023) found that miR-381 binds to EGR1 and upregulates PTEN/P53 to alleviate PD. This evidence concerns the gene SP3 and Parkinson disease.