AKT1 and Parkinson disease: Indeed, it was found that rosmarinic acid (RA) promotes antioxidant gene expression by regulating the AKT/Nrf2 signaling pathway to achieve neuroprotective effects in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced zebrafish PD model, while RA can simultaneously inhibit PTEN expression (Zhao Y. et al., 2020).