In line with previous observations [87], several proteins involved in the NF‐βB and STAT3 signaling pathway related to CLL cell activation, proliferation, survival, adhesion, and homing were also found to be increased in common in CLL samples (samples A–D) at significantly higher levels than in CLL‐like MBL cells (i.e., sample E), suggesting a potential role for this specific signaling pathway in the malignant transformation of the disease. This evidence concerns the gene STAT3 and B-cell chronic lymphocytic leukemia.