Recently, the proteome of CLL cells was analyzed by data‐independent acquisition mass spectrometry (DIA‐MS) reporting a protein landscape of 3314 proteins that identified limited protein abundance buffering and an upregulated protein complex involved in BCR, AKT, MAPK, and PI3K signaling in trisomy 12 CLL [9]. This evidence concerns the gene AKT1 and B-cell chronic lymphocytic leukemia.