In the APP/PS1 mouse model, early depletion of Tregs is associated with an increase in C3+ reactive astrocytes around large amyloid deposits, suggesting that Tregs may play a role in suppressing the pro-inflammatory C3+ reactive astrocytes associated with late-stage amyloid deposition, thereby mitigating neuroinflammation and cognitive impairment [63]. This evidence concerns the gene C3 and Cognitive impairment.