In the context of Alzheimer's disease (ad), a distinct series of thiazole‐piperazine hybrids has recently received wide interest in this field as these compounds exhibited notable inhibitory potential against AChE, with IC50 values calculated as 0.0496 ± 0.002 μM, 0.0317 ± 0.001 μM, and 0.2158 ± 0.010 μM for compounds 3a, 3c, and 3i, respectively [48]. This evidence concerns the gene ACHE and Alzheimer disease.