These results strongly demonstrate that EPHX2 expression is positively associated with several metabolism‐related pathways, including bile acid metabolism, peroxisome, fatty acid metabolism, adipogenesis, and heme metabolism, and inversely associated with numerous common cancer‐related pathways, including MYC targets V2, E2F targets, epithelial‐mesenchymal transition, unfolded protein response, G2M checkpoint, and others (Figure 11C; p < 0.05). This evidence concerns the gene MYC and cancer.