Compared to the control group, RASON-ASO treatment showed a similar inhibition effect on tumor growth as AMG-510 (Fig. 6H-J and Fig. S8A-C), and the combination of AMG-510 and RASON-ASO resulted in a significantly enhanced suppression effect (Fig. 6H-J and Fig. S8A-C), indicating that RASON inhibition synergizes with AMG-510 for clinical treatment. The gene discussed is LINC00511; the disease is neoplasm.