Tau is a microtubule associated protein that functions to stabilize microtubules; however, abnormal aggregation of tau has been reported in a variety of neurodegenerative diseases including AD, frontotemporal dementia (FTD), progressive supranuclear palsy, LRRK2 PD, and others [146, 147]. The gene discussed is MAPT; the disease is progressive supranuclear palsy.