To explore the interaction of SOX2 with LMX1 transcription factors, murine Rb1/Trp53-deficient CPC cells and a human CPC cell line were infected with viruses expressing SOX2, respectively.17 Immunofluorescence showed that SOX2 overexpression increased the expression of LMX1A and LMX1B in infected tumor cells (Figure 5E–G). The gene discussed is RB1; the disease is neoplasm.