LMX1B and neoplasm: To explore the interaction of SOX2 with LMX1 transcription factors, murine Rb1/Trp53-deficient CPC cells and a human CPC cell line were infected with viruses expressing SOX2, respectively.17 Immunofluorescence showed that SOX2 overexpression increased the expression of LMX1A and LMX1B in infected tumor cells (Figure 5E–G).