To determine whether SOX2 supports tumor cell proliferation through regulating LMX1 gene expression, primary tumor cells from Lcre;NICD1 mice were infected with viruses expressing HA-tagged LMX1A or LMX1B, or control viruses, followed by treatment with siRNAs against Sox2 or control siRNAs for 72 h (Figure S8B, S8C). The gene discussed is LMX1B; the disease is neoplasm.