SOX2 and neoplasm: To delete Sox2 in tumor cells, a mouse strain carrying conditional alleles of Sox2 (Sox2flox/flox) was bred with Lcre;NICD1 mice.46Sox2 loss blunted tumor development and restored cuboidal epithelial morphology in Lcre;NICD1;Sox2flox/flox (Lcre;NICD1;Sox2cko) animals (Figure 3B, Figure S3A).