HES5 and neoplasm: Integrative ChIP-seq and RNA-seq studies identified putative SOX2 transcriptional target genes in tumor cells, including markers of progenitors in the rhombic lip, transcriptional regulators of hindbrain development such as Zic1-Zic4, NOTCH targets Hes5 and Hes1, and LMX1A and LMX1B transcription factors that play a crucial role in the development of the rhombic lip and the CP.9,11,47,49 SnRNA-seq and scATAC-seq data confirmed their activities in NOTCH-driven CP tumors.