In this study, single-nucleus RNA sequencing (snRNA-seq) and single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) showed that NOTCH-driven CP tumors partitioned into clusters identified as epithelial-like, mesenchymal, endothelial, immune, neuronal, and glia-like cells, similar to populations in normal CP in mice.3 Though tumor cells reside in an epithelial-like compartment, they arise from binary glial progenitors and exhibit an enrichment of genes associated with glial progenitors in the rhombic lip, including Sox2, Zfp423, and Rspo1. Here, SOX2 is linked to neoplasm.