The expression of granzyme B (GZMB), Contactin associated protein-like 3B (CNTNAP3), SLAM family member 7 (SLAMF7), Imprinted maternallyexpressed transcript (H19), Programmed cell death 1 ligand 2 (PDCD1LG2), Guanylate binding protein 4 (GBP4), Membrane metallo-endopeptidase (MME), Guanylate binding protein 1 (GBP1), Guanylate binding protein 5 (GBP5), CD274 molecule (CD274), CXCL10, Interferon induced protein with tetratricopeptide repeats 1B (IFIT1B), Defensin alpha 4 (DEFA4), and Interleukin 1 receptor type 2 (IL1R2) was upregulated in the RA and RB groups (Fig. 1B). This evidence concerns the gene DEFA4 and retinoblastoma.