LMNA and Hutchinson-Gilford progeria syndrome: Over 90% of HGPS cases result from a single point mutation (p.G608G) in exon 11 of the LMNA (Lamin A/C) gene (Piekarowicz et al. 2019; Koblan et al. 2021), which activates a cryptic splicing site and forms Progerin (Loi et al. 2016; Pablo Mayoral and López-Otín , 2018).