In the ER-positive murine breast cancer cell line EO771, PARP7 had no effect on proliferation but was found to dampen TBK1- and NF-κB-dependent IFN-I signaling, while PARP7 inhibition was shown to stimulate IFN-I signaling and immune cell infiltration (Rasmussen et al, 2023) (Table 2). The gene discussed is TIPARP; the disease is breast cancer.