Stabilized FRA1 negatively regulates interferon regulatory factor 1 (IRF1), which is required for the induction of RIG-I-like receptor (RLR)-encoding genes, and thereby negatively regulates the RIG-I-MAVS-IRF3 signaling axis in lung cancer cells and suppresses caspase 8-driven apoptosis (Manetsch et al, 2023; Naulin et al, 2024). The gene discussed is IRF1; the disease is lung carcinoma.