Identified fusion-driven genomic subtypes of B-ALL were: ETV6::RUNX1, TCF3::PBX1, Philadelphia (Ph) (BCR::ALB1), Ph-like including CRLF2r (CRLF2::IGH; PAX5::MLLT3; MEF2D::CSF1R; EBF1::PDGFRB), MEF2Dr (MEF2D::BCL9; MEF2D::HNRNPUL1), ZNF384r (ZNF384::EP300; TCF3::ZNF384; CREBBP::ZNF384), and DUX4r (DUX4::IGH). The gene discussed is CREBBP; the disease is acute lymphoblastic leukemia.