ESR1 and neoplasm: Significant correlations were found with age > 50 years (P = 1.37E−04), high tumor grade (P = 0.002), Ki67 ≥ 20% (P = 8.64E−05), ER-negative status (P = 1.93E−13), and PgR-negative status (P = 2.99E−10).