However, the expression of known nerve injury-regulated genes Slc12a5 (encoding KCC2 and downregulated by peripheral nerve injury)36 and Bdnf (upregulated by injury)37 as well as Fos and Fos module score were not as robust as in the scRNA-seq data (Extended Data Fig. 7b–f). The gene discussed is SLC12A5; the disease is peripheral nerve injury.