CFLAR and colorectal cancer: Next, to examine whether RIPK1 kinase-mediated cell death also protects colonic epithelial cells against C. rodentium blockade of innate immune signalling, we challenged the murine colorectal cancer cell line, CMT-93, with C. rodentium and ΔnleE and verified that NleE likewise suppresses NF-κB activation and induction of the NF-κB target gene, c-FLIP, in these cells (Appendix Fig. S1A,B).