Another notable example occurs during cytomegalovirus (CMV) infection, where CMV uses viral M45-encoded inhibitor of RIP activation (vIRA) to disrupt RIPK1-RIPK3 interaction to counteract necroptosis upon caspase-8 blockade by viral inhibitor of caspase-8 activation (vICA) (Upton et al, 2010). This evidence concerns the gene CASP8 and cytomegalovirus infection.