In a subpopulation of cells involved in the brain metastasis of lung cancer, aldo-keto reductase family 1 member B10 (AKR1B10) is overexpressed and induces H4K12la-dependent cyclin B1 (CCNB1) transcription by promoting LDHA expression, leading to resistance to pemetrexed chemotherapy agents (Fig. 2d)45. The gene discussed is AKR1B10; the disease is lung cancer.