This distinct metabolic feature is attributed to the induction of specific isozyme expression of glycolytic enzymes such as hexokinase 2 (HK2), phosphofructokinase 1 (PFK1), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA) in cancer cells compared with their counterparts in normal cells3. This evidence concerns the gene PFKFB3 and cancer.