Interestingly, LEL-Fc binding to M1-like cell types (CD45+ CD11b+ F4/80+ MHC-II+ ) was increased in mice with CIA, but its binding to other immune cells, including M2-like cells, B cells and dendritic cells, were unchanged in arthritis induced mice (Fig. 5a and Fig. S12a). This evidence concerns the gene ITGAM and arthritic joint disease.