F5 and stroke disorder: Primary factors include genetic and acquired conditions such as deficiencies in antithrombin, congenital abnormalities in fibrinogen, and mutations in coagulation factors like Factor V Leiden and Factor II 20210A.[8,9] Secondary factors include stroke, prolonged bed rest, advanced age, immobilization, and malignancy.[10,11] Stroke itself is a well-established risk factor for LEDVT due to venous damage, blood stasis, and hypercoagulability, which contribute to thrombus formation.