This suggests that STAT3 inhibitors may enhance radioactive iodine uptake in refractory PTC by reversing immunosuppressive microenvironments.[28] Notably, the IL-6/JAK/STAT3 axis and PI3K-AKT pathway synergistically interact in PTC, forming a positive feedback loop that sustains tumor survival under hypoxic conditions.[29] Such signaling crosstalk may explain the dual inhibitory effects of the identified compounds on both pathways. This evidence concerns the gene PIK3CA and neoplasm.