IL18 and Psoriasiform dermatitis: Moreover, in the same mouse model, high mobility group box 1 protein-induced IL-18 expression and secretion were found to facilitate the formation of psoriasiform dermatitis.[19] Taken together, these studies reveal that IL-18 may be involved in the pathogenesis of pSS by participating in the regulation of immune cells, and these biological activities on T-cell subsets has made IL-18 as a good target of the research in pSS.