IFNA1 and peeling skin syndrome: Environmental, genetic, epigenetic, and hormonal factors are implicated in pSS pathogenesis.[7] In essence, the pathogenesis of pSS is a result of a complex interaction between the activated immune system (including the innate immunity and acquired immunity).[8] The expression of 23 genes in the interferon (IFN) pathways was found to be different between pSS patients and controls.