IFNA1 and peeling skin syndrome: Most of these genes are involved in IFN-α and IFN-β pathways.[9] Notably, helper T cell populations are thought to play an important role in pSS, and some scientists confirm that Th1 cells and Th17 cells initiate SS while Th2 cells and Follicular helper T cell predominate as the disease progresses.[10] Additionally, either a reduced natural killer (NK) cell number or an impaired NK cell function were identified in patients, which might permit the persistence of abnormal autoimmune response.[11]