ZEB1 and Corneal opacity: A notable study investigating the pathogenesis of diabetic wounds uncovered that MALAT1 activates TGF-β1-mediated EMT by promoting the upregulation of ZEB1 expression.[57] In an animal experiment examining the effects of aging, the 3’ isoform of MALAT1 exhibited an age-related increase in retinal oxidative stress and corneal opacity, suggesting its potential significance in investigating the process of aging.