PDGFRB and glioblastoma: For instance, high PDGFRB expression has been found in glioblastoma and invasive triple-negative breast cancer.[7,8] In addition, studies have found that PDGFRB is mainly expressed by mesenchymal cells in epithelial tumors, and PDGFRB signals contribute to invasion and liver metastasis.[9,10] In addition to the increased risk of cancer caused by PDGFRB overexpression, mutations in PDGFRB can also lead to cancer.