Akkaya et al reported that adropin levels in coronary artery disease patients showed a weak correlation with age and creatinine, but did not reach clinical significance.[19] Depboylu et al also found that adropin levels were more closely associated with nutritional status and inflammation in hemodialysis patients, but showed limited correlation with parameters such as creatinine and age.[20] These findings suggest that adropin plays an important role in energy homeostasis and metabolic regulation, but may have less impact on some clinical parameters. The gene discussed is ENHO; the disease is coronary artery disorder.