MALAT1 can affect the expression of NLRP3 by regulating mir-224-5p, while up-regulating mir-224-5p can reduce the inflammatory activation of microglia and ultimately regulate NLRP3/IL-1 in the hippocampus.[107] IH-induced cognitive impairment is closely related to oxidative stress injury in hippocampal neurons. This evidence concerns the gene NLRP3 and Cognitive impairment.