Assay for transposase-accessible chromatin in acute myeloid leukemia samples revealed that high ADGRG1 level correlated with both WNT and Hedgehog signal partway activity and that ADGRG1 suppression led to downregulation, at the RNA level, of “WNT-related” genes, including DVL1 (79). The gene discussed is DVL1; the disease is acute myeloid leukemia.