Since then, it has been shown that ADGRA3 is expressed in both mammary progenitors (13), lacrimal gland progenitors (19), in male and female reproductive tract development (12, 18), in osteoclastogenesis (24), in the brain with upregulation after brain injury (10), as well as playing a role in several cancers (13, 14, 15, 16). This evidence concerns the gene ADGRA3 and cancer.