For instance, EETs have been shown to reduce myocardialinfarct size,7 reduce the cardiotoxic effectsof doxorubicin,13 and attenuate alcohol-inducedcardiac dysfunction.14 The main degradationpathway of EETs is through soluble epoxide hydrolase (sEH), whichhydrolyzes EETs to dihydroxyeicosatrienoic acids (diHETs) (Figure 1). Here, EPHX2 is linked to alcohol dependence.