PGF and trisomy 21: It has been shown that PlGF MoM is also lower in pregnancies with trisomy 2131, and although the impact of PlGF on the overall screening performance for trisomy 21 has been found to be low, it has been suggested that a further improvement in screening for trisomy 21 could be an added benefit of combining first‐trimester screening for aneuploidy and PE using PlGF.14, 31