Consistent with selective expression in the cardiomyocyte lineage (Fig. 2 and SI Appendix, Fig. S9), probands with MYH6 D-mis variants predominantly had isolated CHD (Table 1); only 1/24 probands with transmitted variants and LVO, HLHS, or ASD, had NDD. The gene discussed is MYH6; the disease is Neurodevelopmental delay.