In a recent study, we found a common haplotype block in the genetic region of SOST, which was associated with BMD (rs1513670) [6] and severe periodontitis (classified as periodontitis stages III/IV, grade C; PIII-IV/C) diagnosed in young adults (rs6416905, linkage disequilibrium r2 >  0.8) [29]. This evidence concerns the gene SOST and periodontitis.