After acute intraperitoneal injection of Iso (1.5 mg/kg) for 15 min, the incidence of AF in the FGF23‐CKO group (4.34%, n = 1/23) was significantly decreased compared with the Cre group (33.3%, n = 5/15) (p < 0.05) (Figure 2B). The gene discussed is FGF23; the disease is atrial fibrillation.