KCNH1 and glioblastoma: While several studies revealed that blocking hERG or Eag1 with inhibitors or a genetic knock-down induces cell cycle arrest and apoptosis in glioblastoma cells (Elias et al. 2023), only one study has proposed a sensitizing potential of Eag1 blockade to TMZ treatment in U87 cells (Sales et al. 2016).