Here, we aimed at disentangling the contribution of hERG/Eag1 inhibition to TMZ-induced cytotoxicity and CSEN, using established human glioblastoma cell lines and primary glioblastoma cells, by applying the potent inhibitors astemizole and terfenadine as model substances (Toplak et al. 2022). The gene discussed is KCNH2; the disease is glioblastoma.