The p53, TNF alpha, Bax, and caspase 3, 9 expressions was considerably higher in the groups receiving sono-photo-dynamic treatment with CPL-Micelles than in the PDT or SDT with CPL-Micelles, IRL or US alone without CPL-Micelles, and the untreated DMBA-lymphoma-induced mice. The gene discussed is TP53; the disease is lymphoma.