demonstrating the inhibitory effect (cell cycle arrest; down of progression of cell cycle in in S phase and G2/M phase), as well as destroying tumor cells (decline of cell viability in a dose-dependent manner, necrosis, apoptosis, autophagy) was maximum in presence of CPL-Micelles as sensitizer combined with both laser (-photo) and ultrasound (-sono) activation (SPDT) followed by CPL-Micelles ultrasound only (SDT activation and laser activation only (PDT) and that SPDT superior to SDT and PDT. Here, HEPH is linked to neoplasm.