In addition, all DMBA-lymphoma-induced mice irradiated with ultrasound, laser, or ultrasound and laser combination only groups demonstrated significantly declined levels of p53, TNF alpha, Bax, and caspase (3, 9) expressions and notably increased levels of VEGF and Bcl-2 expressions when regarding to the healthy control group of mice. The gene discussed is TP53; the disease is lymphoma.