Regarding to the untreated DMBA-lymphoma-induced control group, the delivery of CPL-Micelles to the IRL, US, and combination of IRL and US activated groups led to significant decline in the expressions of the Bcl-2 and VEGF genes and elevation in the p53, Bax, TNF alpha, and caspase (3, 9) expressions. The gene discussed is TP53; the disease is lymphoma.